Define the control failure
The first task is to identify the disease-linked loss of regulation and the useful function that remains. Aeviant maps the relevant tissue, endogenous signals, timing and physiological conditions before choosing a therapeutic strategy.
Specify the therapeutic response
Each program states what the intervention should do, where that action should occur and which biological inputs should shape it. This specification defines the program’s required pharmacology and its relevant dimensions of selectivity.
Design the intervention
The biological requirement guides target selection, modality and molecular design. Literature review and computational analysis characterize the system, generate possible interventions and challenge them against the behaviour the program is intended to produce.
Build the evidence
Computational work identifies hypotheses ready for direct testing. Synthesis, experimental pharmacology, exposure, safety and efficacy studies supply the evidence for later decisions. Predefined criteria determine whether a program advances, is redesigned, pauses or stops.