Research integrity

Research decisions

For an analysis intended to decide whether a program advances, changes or stops, Aeviant records the question, method, metric and decision threshold before the work begins.

Aeviant evaluates the result against the method and criterion recorded when the work began. A later change is dated, explained and applied only to later work.

Exploratory analyses are identified as exploratory in the project record. They may define a later test, but a later criterion does not change the status of an earlier result. Results that fail a criterion or conflict with the working hypothesis remain in the project record and are considered in later decisions.

Research records and source checks

For computational work used in a program decision, Aeviant’s record identifies the input data and their source, analysis method, software or model version, parameters that affect the result and output reviewed for that decision.

Before publishing a scientific claim, Aeviant checks that the cited source supports the wording. The review also considers limitations of the source and relevant evidence that disagrees with the claim.

Public scientific claims

On public science pages, Aeviant uses labels to distinguish established biology, preclinical evidence, its own interpretation, program objectives and claims that require validation.

When a claim relies on computational work, Aeviant identifies it as computational and states whether the result has been tested experimentally. Aeviant does not report a computational result as measured binding, pharmacology, safety, efficacy or activity in a living system.

If confidential technical detail cannot be published, Aeviant still states whether the claim comes from cited literature, Aeviant analysis or a program objective, and whether it has experimental validation.

Corrections and concerns

If Aeviant identifies an error that changes a public claim, a correction or retraction in a source, or new evidence that changes the claim, it reviews the affected material and updates or removes it.

When a correction changes the meaning of a public scientific claim, Aeviant adds a dated note describing what changed and whether the conclusion was affected.

Questions or concerns about the accuracy or conduct of Aeviant’s research may be sent to [email protected]. Aeviant records the concern, preserves the relevant project material and reviews the underlying work. The review determines whether public material, an analysis, a program decision, access or responsibilities must change.