Molecular selectivity describes preference for an intended target. Aeviant uses physiological selectivity as a working term for the fit between a therapeutic action and the biological conditions in which that action is useful.
What biological state means
Biological state is the condition in which a target and its surrounding system are operating. Relevant inputs can include tissue, endogenous signal, activity pattern, timing, disease context and the regulatory pathways already engaged.
The relevant state is defined separately for each program. The definition must be specific enough to shape a pharmacological hypothesis and an experiment.
What the program evaluates
A program evaluates target and subtype preference, tissue context, timing, signalling consequences, dependence on relevant biological inputs and the resulting physiological function. Each dimension has its own evidence requirement. Direct testing determines whether the intended state dependence and functional profile are present.